The human gut microbiota is known as the "second brain". Intestinal flora is a large number of microorganisms in the human gut, which is a highly diverse bacterial homeostasis system. If this homeostasis is out of balance, the intestinal flora will be disturbed, which will affect the physical health. A growing body of research has shown that intestinal flora participates in two-way communication between gut and brain through gut-brain axis (GBA) and is strongly associated with Alzheimer's disease (AD). At present, there is still a lack of effective treatment for AD. Recent studies have shown that polyphenols play a neuroprotective role by exerting their anti-inflammatory and antioxidant effects. This topic refers to a large number of recent literatures in the same field and makes a comprehensive review of them. It was found that polyphenols with complex structure could not be directly digested and absorbed by human organism, and their bioavailability was low, which affected the effective play of their health effects. The secretory enzymes in the intestinal flora convert them into small molecular metabolites that are biologically active and easy for the body to absorb. At the same time, polyphenols can the composition and function of intestinal flora by acting on its growth or metabolism, and further act on immune, endocrine and intestinal neural pathways in GBA, forming a complex network of relationships. By exerting its neuroprotective effect, it is expected to achieve the purpose of preventing and treating AD.
| Published in | World Journal of Public Health (Volume 8, Issue 2) |
| DOI | 10.11648/j.wjph.20230802.11 |
| Page(s) | 43-49 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Alzheimer's Disease, Intestinal Flora, Gut-Brain Axis, Polyphenols
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APA Style
Song Chenmeng, Wu Ming, Li Chune, Zhang Jingjing, Li Xiping. (2023). Research Progress of Polyphenols in the Prevention and Treatment of AD by Regulating Intestinal Flora. World Journal of Public Health, 8(2), 43-49. https://doi.org/10.11648/j.wjph.20230802.11
ACS Style
Song Chenmeng; Wu Ming; Li Chune; Zhang Jingjing; Li Xiping. Research Progress of Polyphenols in the Prevention and Treatment of AD by Regulating Intestinal Flora. World J. Public Health 2023, 8(2), 43-49. doi: 10.11648/j.wjph.20230802.11
AMA Style
Song Chenmeng, Wu Ming, Li Chune, Zhang Jingjing, Li Xiping. Research Progress of Polyphenols in the Prevention and Treatment of AD by Regulating Intestinal Flora. World J Public Health. 2023;8(2):43-49. doi: 10.11648/j.wjph.20230802.11
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Download@article{10.11648/j.wjph.20230802.11,
author = {Song Chenmeng and Wu Ming and Li Chune and Zhang Jingjing and Li Xiping},
title = {Research Progress of Polyphenols in the Prevention and Treatment of AD by Regulating Intestinal Flora},
journal = {World Journal of Public Health},
volume = {8},
number = {2},
pages = {43-49},
doi = {10.11648/j.wjph.20230802.11},
url = {https://doi.org/10.11648/j.wjph.20230802.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjph.20230802.11},
abstract = {The human gut microbiota is known as the "second brain". Intestinal flora is a large number of microorganisms in the human gut, which is a highly diverse bacterial homeostasis system. If this homeostasis is out of balance, the intestinal flora will be disturbed, which will affect the physical health. A growing body of research has shown that intestinal flora participates in two-way communication between gut and brain through gut-brain axis (GBA) and is strongly associated with Alzheimer's disease (AD). At present, there is still a lack of effective treatment for AD. Recent studies have shown that polyphenols play a neuroprotective role by exerting their anti-inflammatory and antioxidant effects. This topic refers to a large number of recent literatures in the same field and makes a comprehensive review of them. It was found that polyphenols with complex structure could not be directly digested and absorbed by human organism, and their bioavailability was low, which affected the effective play of their health effects. The secretory enzymes in the intestinal flora convert them into small molecular metabolites that are biologically active and easy for the body to absorb. At the same time, polyphenols can the composition and function of intestinal flora by acting on its growth or metabolism, and further act on immune, endocrine and intestinal neural pathways in GBA, forming a complex network of relationships. By exerting its neuroprotective effect, it is expected to achieve the purpose of preventing and treating AD.},
year = {2023}
}
TY - JOUR T1 - Research Progress of Polyphenols in the Prevention and Treatment of AD by Regulating Intestinal Flora AU - Song Chenmeng AU - Wu Ming AU - Li Chune AU - Zhang Jingjing AU - Li Xiping Y1 - 2023/04/11 PY - 2023 N1 - https://doi.org/10.11648/j.wjph.20230802.11 DO - 10.11648/j.wjph.20230802.11 T2 - World Journal of Public Health JF - World Journal of Public Health JO - World Journal of Public Health SP - 43 EP - 49 PB - Science Publishing Group SN - 2637-6059 UR - https://doi.org/10.11648/j.wjph.20230802.11 AB - The human gut microbiota is known as the "second brain". Intestinal flora is a large number of microorganisms in the human gut, which is a highly diverse bacterial homeostasis system. If this homeostasis is out of balance, the intestinal flora will be disturbed, which will affect the physical health. A growing body of research has shown that intestinal flora participates in two-way communication between gut and brain through gut-brain axis (GBA) and is strongly associated with Alzheimer's disease (AD). At present, there is still a lack of effective treatment for AD. Recent studies have shown that polyphenols play a neuroprotective role by exerting their anti-inflammatory and antioxidant effects. This topic refers to a large number of recent literatures in the same field and makes a comprehensive review of them. It was found that polyphenols with complex structure could not be directly digested and absorbed by human organism, and their bioavailability was low, which affected the effective play of their health effects. The secretory enzymes in the intestinal flora convert them into small molecular metabolites that are biologically active and easy for the body to absorb. At the same time, polyphenols can the composition and function of intestinal flora by acting on its growth or metabolism, and further act on immune, endocrine and intestinal neural pathways in GBA, forming a complex network of relationships. By exerting its neuroprotective effect, it is expected to achieve the purpose of preventing and treating AD. VL - 8 IS - 2 ER -
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