| Peer-Reviewed

Unilateral Retinoblastoma Presentation in a Latin-American Teenager: A Case Report and Literature Review

Received: 2 December 2021     Accepted: 20 December 2021     Published: 29 December 2021
Views:       Downloads:
Abstract

Background: Retinoblastoma is the most common intraocular mass in children—typically presenting in infants under 5 years of age—with a mean age of 24 months in unilateral cases, and 12 months in bilateral cases. Late-onset retinoblastoma and its presentation in adults is extremely rare; however, it should always be considered for the differential diagnosis of an intraocular mass originating from the retina. Due to the life-threatening nature of this disease, early diagnosis and prompt treatment are crucial for a good prognosis. Objective: A tumor case presentation and multidisciplinary study of a female young adult. Method: A case presentation study of a Hispanic teenager with a unilateral retinoblastoma and vitreous exudation resembling a large snowbank. The patient underwent complete ophthalmological examination and subsequent enucleation, with histopathological confirmation of retinoblastoma accompanied by chemotherapy. Conclusion: Retinoblastoma presenting as an intraocular mass in a young adult should always be considered as a differential diagnosis. Echography is crucial to obtaining a diagnosis, as well as dictating precise and adequate treatment. We review the literature regarding cases of retinoblastoma, demonstrating that most exhibited differentiated characteristics and were sporadic in nature; in most cases, the eye could not be saved. Review of late-onset retinoblastomas was therefore conducted to enrich our existing knowledge, as well as to prevent making the same mistakes when facing a similar difficult diagnosis.

Published in International Journal of Ophthalmology & Visual Science (Volume 6, Issue 4)
DOI 10.11648/j.ijovs.20210604.23
Page(s) 267-272
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Retinoblastoma, Intraocular Mass, Leukocoria, Echography and Enucleation

References
[1] Sengupta S, Pan U, Ketan K. Adult onset retinoblastoma. Indian J Ophthalmol. 2016; 64 (7): 486–491. https://doi.org/10.4103/0301-4738.190099.
[2] Zhou L, Zhu XH, Zhang K, et al. Case report: Adult retinoblastoma progression in 19 months. Optom Vis Sci. 2020; 97 (11): 1010–1016. https://doi.org/10.1097/OPX.0000000000001602.
[3] Wells JR, Aaberg TM, Shields CL, et al. Retinoblastoma in a 48-year-old woman. Retin. Cases Brief Rep. 2011; 5 (1): 22–25. https://doi.org/10.1097/ICB.0b013e3181e17fa6.
[4] Shields CL, Shields JA, Shah P. Retinoblastoma in older children. Ophthalmology. 1991; 98: 395–399. https://doi.org/10.1016/s0161-6420(91)32283-8.
[5] Biwas J, Mani B, Shanmugam MP, et al. Retinoblastoma in adults. Report of three cases and review of the literature. Surv ophthalmol. 2000; 44 (5): 409–414. https://doi.org/10.1016/S0039-6257(99)00132-0.
[6] Nork TM, Millecchia LL, De Venecia GB, et al. Immunochytochemical features of retinoblastoma in an adult. Arch Ophthalmol. 1996; 114 (11): 1402–1406. https://doi.org/10.1001/archopht.1996.01100140602013.
[7] Rashead SA, Elkhamary SM, Sheikh OA, et al. Adult presentation of retinoblastoma in Saudi patient. Saudi J Ophthalmol. 2020; 34 (2): 136–138. https://doi.org/10.4103/1319-4534.305046.
[8] De jong P, Mooy CM, Stoter G, et al. Late-onset retinoblastoma in a well-functioning fellow eye. Ophthalmology. 2006; 113 (6): 1040–1044. https://doi.org/10.1016/j.ophtha.2006.02.047.
[9] Odashiro AN, Pereira PR, Filho JP, et al. Retinoblastoma in an adult: case report and literature review. Can J Ophthalmol. 2005; 40 (2): 188–191. https://doi.org/10.1016/S0008-4182(05)80032-8.
[10] Hernandez I, Rios D, Lome C, et al. Retinoblastoma in the adolescent. Unusual clinical and histopathology findings. Arch Soc Esp Oftalmol. 2016; 91 (3): 149–152. https://doi.org/10.1016/j.oftal.2015.12.007. [Spanish, English].
[11] Mietz H, Hutton WL, Front RL. Unilateral retinoblastoma in an adult. Ophthalmology. 1997; 104 (1): 43–47. https://doi.org/10.1016/s0161-6420(97)30363-7.
[12] Singh SK, Das D, Bhattacharjee H, et al. A rare case of adult onset retinoblastoma. Oman J Ophthalmol. 2011; (4) 1: 25–27. https://doi.org/10.4103/0974-620X.77659.
[13] Sharifzadeh M, Ghassemi F, Amoli FA, et al. Retinoblastoma in adults: a case report and literature review. J Ophthalmic Vis Res. 2014; 9 (3): 388–391. https://doi.org/10.4103/2008-322X.143382.
[14] Khetan V, Bindu A, Kamat P, et al. Failure of globe conservation in a case of adult onset retinoblastoma. Middle East Afr J Ophthalmol. 2014; 21 (4): 358–360. https://doi.org/10.4103/0974-9233.142280.
[15] Kalikili S, Shields CL, Gupta A, et al. Newly diagnosed active retinoblastoma in adults. Retina. 2015; 35 (12): 2483–2488. https://doi.org/10.1097/IAE.0000000000000612.
[16] Riazi-Esfahani H, Masoomian B, Ghassemi F. Intra-arterial chemotherapy: New hope for adult retinoblastoma treatment – A case report and brief review. Case reports in ophthalmological Medicine. 2021; 2021: 6639900. https://doi.org/10.1155/2021/6639900.
[17] McMahon JF, Jabbour P, Shields CL. Retinoblastoma in a 23-year-old adult treated with primary intra-arterial and intravitreal chemotherapy. Oman J Ophthalmol. 2019; 12 (2): 119–121. https://doi.org/10.4103/ojo.OJO_162_2018.
[18] Magan T, Khoo CT, Jabbour PM, et al. Intra-arterial chemotherapy for adult onset retino- blastoma in a 32-year-old man. Journal of Pediatric Ophthalmology and Strabismus. 2016; 53: e43–e46. https://doi.org/10.3928/01913913-20160722-01.
Cite This Article
  • APA Style

    Erick Andres Quiroz-Gonzalez, Miguel Angel Quiroz-Reyes, Cristina Gonzalez-Gonzalez, Roberto Loaeza-Castrejon, Luis Haro-Morlett, et al. (2021). Unilateral Retinoblastoma Presentation in a Latin-American Teenager: A Case Report and Literature Review. International Journal of Ophthalmology & Visual Science, 6(4), 267-272. https://doi.org/10.11648/j.ijovs.20210604.23

    Copy | Download

    ACS Style

    Erick Andres Quiroz-Gonzalez; Miguel Angel Quiroz-Reyes; Cristina Gonzalez-Gonzalez; Roberto Loaeza-Castrejon; Luis Haro-Morlett, et al. Unilateral Retinoblastoma Presentation in a Latin-American Teenager: A Case Report and Literature Review. Int. J. Ophthalmol. Vis. Sci. 2021, 6(4), 267-272. doi: 10.11648/j.ijovs.20210604.23

    Copy | Download

    AMA Style

    Erick Andres Quiroz-Gonzalez, Miguel Angel Quiroz-Reyes, Cristina Gonzalez-Gonzalez, Roberto Loaeza-Castrejon, Luis Haro-Morlett, et al. Unilateral Retinoblastoma Presentation in a Latin-American Teenager: A Case Report and Literature Review. Int J Ophthalmol Vis Sci. 2021;6(4):267-272. doi: 10.11648/j.ijovs.20210604.23

    Copy | Download

  • @article{10.11648/j.ijovs.20210604.23,
      author = {Erick Andres Quiroz-Gonzalez and Miguel Angel Quiroz-Reyes and Cristina Gonzalez-Gonzalez and Roberto Loaeza-Castrejon and Luis Haro-Morlett and Armando Bautista-Barba and Emiliano Fulda-Graue and Federico Graue-Wiechers},
      title = {Unilateral Retinoblastoma Presentation in a Latin-American Teenager: A Case Report and Literature Review},
      journal = {International Journal of Ophthalmology & Visual Science},
      volume = {6},
      number = {4},
      pages = {267-272},
      doi = {10.11648/j.ijovs.20210604.23},
      url = {https://doi.org/10.11648/j.ijovs.20210604.23},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20210604.23},
      abstract = {Background: Retinoblastoma is the most common intraocular mass in children—typically presenting in infants under 5 years of age—with a mean age of 24 months in unilateral cases, and 12 months in bilateral cases. Late-onset retinoblastoma and its presentation in adults is extremely rare; however, it should always be considered for the differential diagnosis of an intraocular mass originating from the retina. Due to the life-threatening nature of this disease, early diagnosis and prompt treatment are crucial for a good prognosis. Objective: A tumor case presentation and multidisciplinary study of a female young adult. Method: A case presentation study of a Hispanic teenager with a unilateral retinoblastoma and vitreous exudation resembling a large snowbank. The patient underwent complete ophthalmological examination and subsequent enucleation, with histopathological confirmation of retinoblastoma accompanied by chemotherapy. Conclusion: Retinoblastoma presenting as an intraocular mass in a young adult should always be considered as a differential diagnosis. Echography is crucial to obtaining a diagnosis, as well as dictating precise and adequate treatment. We review the literature regarding cases of retinoblastoma, demonstrating that most exhibited differentiated characteristics and were sporadic in nature; in most cases, the eye could not be saved. Review of late-onset retinoblastomas was therefore conducted to enrich our existing knowledge, as well as to prevent making the same mistakes when facing a similar difficult diagnosis.},
     year = {2021}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Unilateral Retinoblastoma Presentation in a Latin-American Teenager: A Case Report and Literature Review
    AU  - Erick Andres Quiroz-Gonzalez
    AU  - Miguel Angel Quiroz-Reyes
    AU  - Cristina Gonzalez-Gonzalez
    AU  - Roberto Loaeza-Castrejon
    AU  - Luis Haro-Morlett
    AU  - Armando Bautista-Barba
    AU  - Emiliano Fulda-Graue
    AU  - Federico Graue-Wiechers
    Y1  - 2021/12/29
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ijovs.20210604.23
    DO  - 10.11648/j.ijovs.20210604.23
    T2  - International Journal of Ophthalmology & Visual Science
    JF  - International Journal of Ophthalmology & Visual Science
    JO  - International Journal of Ophthalmology & Visual Science
    SP  - 267
    EP  - 272
    PB  - Science Publishing Group
    SN  - 2637-3858
    UR  - https://doi.org/10.11648/j.ijovs.20210604.23
    AB  - Background: Retinoblastoma is the most common intraocular mass in children—typically presenting in infants under 5 years of age—with a mean age of 24 months in unilateral cases, and 12 months in bilateral cases. Late-onset retinoblastoma and its presentation in adults is extremely rare; however, it should always be considered for the differential diagnosis of an intraocular mass originating from the retina. Due to the life-threatening nature of this disease, early diagnosis and prompt treatment are crucial for a good prognosis. Objective: A tumor case presentation and multidisciplinary study of a female young adult. Method: A case presentation study of a Hispanic teenager with a unilateral retinoblastoma and vitreous exudation resembling a large snowbank. The patient underwent complete ophthalmological examination and subsequent enucleation, with histopathological confirmation of retinoblastoma accompanied by chemotherapy. Conclusion: Retinoblastoma presenting as an intraocular mass in a young adult should always be considered as a differential diagnosis. Echography is crucial to obtaining a diagnosis, as well as dictating precise and adequate treatment. We review the literature regarding cases of retinoblastoma, demonstrating that most exhibited differentiated characteristics and were sporadic in nature; in most cases, the eye could not be saved. Review of late-onset retinoblastomas was therefore conducted to enrich our existing knowledge, as well as to prevent making the same mistakes when facing a similar difficult diagnosis.
    VL  - 6
    IS  - 4
    ER  - 

    Copy | Download

Author Information
  • Ophthalmology Department, Institute of Ophthalmology, National Autonomous University of Mexico, Mexico City, Mexico

  • Retina Service, Institute of Ophthalmology, National Autonomous University of Mexico. Mexico City, Mexico

  • Ultrasonographic Department, Institute of Ophthalmology, National Autonomous University of Mexico, Mexico City, Mexico

  • Retina Service, Institute of Ophthalmology, National Autonomous University of Mexico. Mexico City, Mexico

  • Ophthalmology Department, Institute of Ophthalmology, National Autonomous University of Mexico, Mexico City, Mexico

  • Ophthalmology Department, Institute of Ophthalmology, National Autonomous University of Mexico, Mexico City, Mexico

  • Retina Service, Institute of Ophthalmology, National Autonomous University of Mexico. Mexico City, Mexico

  • Retina Service, Institute of Ophthalmology, National Autonomous University of Mexico. Mexico City, Mexico

  • Sections